Advanced Pathophysiology


This module is designed to cultivate leading edge knowledge and in depth understanding of the scientific basis of health and dysfunction of selective systems in an integrative context and appraise current and future treatment options.


The aim of this Module is to provide the student with a detailed understanding of (i) normal function, (ii) molecular and systemic pathogenesis, (iii) diagnostic, investigative and monitoring approaches, and (iv) clinical management/treatment of selected diseases/conditions.

Learning Outcomes

By the end of this module the student should be able to:

1.  Critically evaluate seminal and leading−edge literature reflecting current knowledge and understanding of a selected pathology.

2.  Describe and explain the foundation principles (Qualitative and quantitative) of selected physiological systems and their major diseases/dysfunctions.

3.  Relate the pathogenomics of selected systemic and trans−system pathologies to their detection, monitoring and management by clinical biochemistry, pathology and other laboratory services.

4.  Appraise the current knowledge and understanding of a selected area of disease physiology, including its molecular and cellular pathogenesis, current and emerging treatment modalities.

Indicative Content

1 Central Nervous system pathology.

A range of neuropathological disorders split into four clear categories. A: Neurodegenerative disorders e.g. Parkinson’s, Huntington’s, Alzheimer’s. B: Strokes – e.g. Haemoragic stroke, Ischaemic stroke,and transient ischemic attacks. C: Acute brain injury – Primary and Secondary injuries. D: Brain tumours – e.g. astrocytoma. ependymoma,oligodendroglioma

2 Reproductive/Developmental pathophysiology.

A: Male UG disorders. B: Female reproductive system disorders. C: Infertility: diagnosis and treatment. D: Downs syndrome: clinical diagnosis.

3 Metabolic disorders

Causes, consequences, comorbidities, treatment and models of A: Diabetes. B: Obesity. C: Metabolic syndrome and their interrelations.

Statement on Teaching, Learning and Assessment

This module will be delivered as a series of lectures and associated lectorials including journal clubs. The first phase (Phase 1, weeks 1-6) will involve lectorial−guided, student−centred foundation study of background material that integrates and enhances diffuse threads studied at lower levels. Material will be closely specified and be made available at or shortly before the start of the module. Phase 2 (weeks 8 -13) will involve each content area delivering a limited set of lectorials/journal clubs to appraise students of current key questions, challenges and research/clinical thrusts. These phase 2 learning formats will guide and enable students towards undertaking enquiry− based learning aimed at developing their integrative knowledge and critical evaluation which will be the primary skills focus for their assessment.

Teaching and Learning Work Loads

Total 200
Lecture 0
Tutorial/Seminar 36
Supervised Practical Activity 0
Unsupervised Practical Activity 0
Assessment 100
Independent 64

Guidance notes

Credit Value – The total value of SCQF credits for the module. 20 credits are the equivalent of 10 ECTS credits. A full-time student should normally register for 60 SCQF credits per semester.


We make every effort to ensure that the information on our website is accurate but it is possible that some changes may occur prior to the academic year of entry. The modules listed in this catalogue are offered subject to availability during academic year 2019/10 , and may be subject to change for future years.