This module provides an integrative study of how cells in the body function to defend against injury and disease
The aim of this Module is to provide a holistic view of defence against injury and disease including the mechanisms of cell proliferation and cell cycle control.
By the end of this module the student should be able to:
1. Discuss the roles of the main components of the immune system and explain how they provide a coordinated response to pathogens.
2. Evaluate the use of antibodies as molecular probes and detection systems.
3. Apply knowledge of the immune system to the processes of vaccine development and passive antibody therapies.
4. Recognise the mechanisms that regulate proliferation and differentiation in eukaryotic cells.
1 Immune system
Innate & acquired immune systems. Specific & Non- specific defence mechanisms. The immune response. Molecular biology of T & B cell responses to antigens. Clonal selection and expansion. Role of lymphokines. Opsonisation, complement activation. Active & passive immunity, Structure, function of antibody molecules. Classes of immunoglobulins. Roles of antibodies in disease diagnosis and control. Rational vaccine design & epitope structure. Identification of B & T cell epitopes. Adjuvants.
2 Antibodies as Molecular Probes
Diagnostic systems based on antibody-antigen interaction. Agglutination, Precipitation reactions. Antibody titres. Solid phase assays. RIA, ELISA, Immunofluorescence etc. Direct, Indirect and sandwich assays. Use of serological methods in diagnosis of infectious diseases and forensic applications such as body fluid identification
3 Cell biology
Basis of cellular energy systems, regulation of cell growth and proliferation; cell cycle checkpoints; growth factors, principle of differentiation, tissue repair.
Statement on Teaching, Learning and Assessment
The module has 5 lab sessions.
Teaching and Learning Work Loads
|Supervised Practical Activity||15|
|Unsupervised Practical Activity||0|
Credit Value – The total value of SCQF credits for the module. 20 credits are the equivalent of 10 ECTS credits. A full-time student should normally register for 60 SCQF credits per semester.
We make every effort to ensure that the information on our website is accurate but it is possible that some changes may occur prior to the academic year of entry. The modules listed in this catalogue are offered subject to availability during academic year 2017/18 , and may be subject to change for future years.